Napoli: Romantic Naples, two hours south of Rome, is the largest city in southern Italy. It has some of the world's best opera and theatre houses and is often called an open-air museum, due to its many historic statues and monuments. Naples is full of historical buildings, squares and churches plus a host of modern amenities and fantastic nightlife opportunities. Looming in the shadow of the legendary Mt. Vesuvius, this is a truly epic tourist destination.